Research Paper Volume 12, Issue 14 pp 14542—14555

Higher expression of cell division cycle-associated protein 5 predicts poorer survival outcomes in hepatocellular carcinoma

Figure 1. CDCA5 is upregulated in HCC tissues and predicts poorer survival outcomes. (A) Representative IHC staining of CDCA5 in HCC and paired normal tissues. (B) The relative protein level of CDCA5 is significantly higher in HCC tissues than in adjacent normal tissue (upper panel). Data represent the mean±SD. ***, p< 0.001. This finding was further validated by comparing CDCA5 expression in tumor and patient-matched adjacent normal tissues (lower panel). (C) Higher expression of CDCA5 predicts poorer survival outcomes in patients with HCC. (D) Multivariable Cox regression analysis shows that CDCA5 is an independent risk factor for both OS (upper panel) and DFS (lower panel). Independent prognostic factors, including CDCA5 expression and other clinical parameters, were assessed using the multivariate Cox proportional hazards model among the variables found to be significant using univariate analysis. The HRs are presented as the means with 95% confidence interval. Differences with p< 0.05 (Red) were considered significant.