Figure 4. Integration of epigenetic change and gene expression between CDCA5-high and -low patients. (A) Volcano plot of differentially expressed miRNAs between CDCA5-high and -low groups. (B) Regulation of gene expression by miRNA plot as network in cytoscape. (C) Dendrogram indicating expression of different gene modules in patients involved in WGCNA analysis. (D) Correlation between module eigengenes and the expression level of the CDCA5 (low vs. high). (E) Venn diagrams demonstrating the number of genes within module turquoise, as well as the overlay with up-regulated genes identified from RNAseq and oncogenes. (F) Local regression curves (Spearman rank correlation) between expression of CDCA5 and 4 oncogenes identified in module turquoise.