Research Paper Volume 12, Issue 14 pp 14019—14036

Metformin administration during pregnancy attenuated the long-term maternal metabolic and cognitive impairments in a mouse model of gestational diabetes

Figure 6. Identification of significant metabolites in the ovary. (A) OPLS-DA and S-plot were used to detect metabolites that discriminated between HFD+vehicle (red) and LFD+vehicle (green). (B) OPLS-DA and S-plot were used to detect metabolites that discriminated between HFD+vehicle (red) and HFD+metformin (green). In S-plot, the blue circles indicate significant metabolites with a VIP of > 1, p-value <0.05, and P(corr) >0.5.