Research Paper Volume 12, Issue 14 pp 14019—14036

Metformin administration during pregnancy attenuated the long-term maternal metabolic and cognitive impairments in a mouse model of gestational diabetes

Figure 7. Significant ovary metabolites common to the LFD and metformin treatment groups. (A) SUS-plot. The red circles represent the metabolites common to both OPLS-DA models (LFD vs HFD and HFD+metformin vs HFD). The blue circles represent metabolites in at least one of the two OPLS-DA models. (B) The heatmap illustrates the levels of the final shortlisted metabolites in each group. The relative concentrations of metabolites were log2 transformed and Pareto scaled. Red color indicates a higher level, while green color indicates a lower level.