Research Paper Volume 12, Issue 14 pp 14718—14735

Demethoxycurcumin analogue DMC-BH inhibits orthotopic growth of glioma stem cells by targeting JNK/ERK signaling

Figure 4. DMC-BH-induced apoptosis in GSCs is mediated by JNK/ERK signaling. (C) Caspase-3 activity measured after incubation with ERK inhibitor U0126 (20 μM) or JNK inhibitor SP600125 (30 μM). (D) Phosphorylated levels of MAPK-related proteins analyzed in DMC-BH-treated GSCs in the presence of U0126 (20 μM) or SP600125 (30 μM); n =3.