Priority Research Paper Volume 12, Issue 12 pp 11185—11199

The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan

Figure 3. Midlife humanin treatment improves metabolic health in mice. Twice weekly treatment with HNG in midlife improves weight (A) without changing food intake (B). There were also improvements in body composition with a decreased values in visceral fat (C), an increase in lean body mass (D), and no change in subcutaneous fat (E). Although there was no significant difference in lifespan with this low of a dose of humanin (F), there was a significant decrease in circulating IGF-I (G) and a trend (p<.1) for leptin (H). *indicates p<.05 +indicates p<.10.