Research Paper Volume 12, Issue 14 pp 14819—14829

ACE2 activator diminazene aceturate ameliorates Alzheimer's disease-like neuropathology and rescues cognitive impairment in SAMP8 mice

Figure 2. DIZE reduced Aβ1-42 levels in the brain of SAMP8 mice. The levels of TBS-soluble Aβ1-42 in the brain were detected by ELISA. Data were analyzed by one-way ANOVA followed by Tukey’s post hoc test. Columns represent mean ± SD (n=8 per group). *P<0.05 versus age-matched vehicle-treated SAMR1 control mice. #P<0.05 versus vehicle-treated SAMP8 mice.