Research Paper Volume 12, Issue 14 pp 14849—14862

Targeting CCL20 inhibits subarachnoid hemorrhage-related neuroinflammation in mice

Figure 3. The effects of CCL20 on neurological deficits and brain edema after SAH. Various doses of CCL20-neutralizing antibody (1 μg/4 μl, 5 μg/4 μl and 7 μg/4 μl) or an equal volume IgG were administered into the brains of mice before SAH. Neurological deficits (A) (n = 15 per group), beam balance tests (B) (n = 15 per group) and brain edema (C) (n = 5 per group) were determined at 24 h and 72 h after SAH. Data were presented as mean ± SD. *P < 0.05, **P < 0.01 vs. the sham group. #P < 0.01, ##P < 0.01 vs. the SAH+IgG group.