Research Paper Volume 12, Issue 14 pp 14885—14896

Circular RNA DHX33 promotes malignant behavior in ccRCC by targeting miR-489-3p/MEK1 axis

Figure 5. circDHX33/miR-489-3p axis in ccRCC. (A, B) The level of miR-489-3p in ccRCC tissues and cell lines was estimated with RT-qPCR. (C, D) Low miR-489-3p levels correlated with poor overall survival rate in patients. (E) circDHX33 expression was negatively correlated with miR-489-3p expression in ccRCC tissues. (F) circDHX33 negatively regulated expression of miR-489-3p in 786O and A498 cells. (G, H) miR-489-3p suppression abolished the effects of circDHX33 inhibition on 786O cells proliferation and invasion abilities. *p<0.05, **p<0.01.