Figure 7. circDHX33/miR-489-3p/MEK1 axis in ccRCC. (A) MiR-489-3p suppression in 786O and A498 cells abolished the effects of circDHX33 inhibition on MEK1 expression. (B) circDHX33 expression was positively correlated with MEK1 expression in ccRCC tissues. (C, D) MEK1 overexpression abolished the effects of circDHX33 inhibition on 786O cells proliferation and invasion abilities. *p<0.05, **p<0.01.