Research Paper Volume 12, Issue 14 pp 14918—14932

RP11-295G20.2 facilitates hepatocellular carcinoma progression via the miR-6884-3p/CCNB1 pathway

Figure 4. miR-6884-3p overexpression inhibits the growth, migration and invasion of HCC cells. (A, B) Hep3B and MHCC-97H cells transfected with the miR-6884-3p mimics or miR-NC were collected. These cells were subjected to CCK-8 and colony formation assays to determine cell proliferation and colony formation capacity, respectively. *P < 0.05 vs. the miR-NC group. (C) Flow-cytometric determination of apoptotic rate of Hep3B and MHCC-97H cells after miR-6884-3p overexpression. *P < 0.05 vs. group miR-NC. (D, E) Transwell migration and invasion assays were used to the effect of miR-625 overexpression on the migration and invasion of Hep3B and MHCC-97H cells, respectively. Representative images and quantification are presented. *P < 0.05 vs. group miR-NC.