Research Paper Volume 12, Issue 14 pp 14978—14989

Inhibition of miRNA-152-3p enhances diabetic wound repair via upregulation of PTEN

Figure 2. PTEN expression fluctuates with simulation by glucose. (A) The PTEN level was lower in DFU patients than in nondiabetic controls as measured by qRT-PCR analysis. (B) PTEN level was determined via qRT-PCR in HUVECs treated with D-glucose. (C) PTEN expression was significantly decreased 3 and 7 days after wounding in diabetic mice compared with nondiabetic mice. Data are the mean ± SD of three independent experiments. *P <0.05, **P <0.01, ***P <0.001.