Figure 2. PTEN expression fluctuates with simulation by glucose. (A) The PTEN level was lower in DFU patients than in nondiabetic controls as measured by qRT-PCR analysis. (B) PTEN level was determined via qRT-PCR in HUVECs treated with D-glucose. (C) PTEN expression was significantly decreased 3 and 7 days after wounding in diabetic mice compared with nondiabetic mice. Data are the mean ± SD of three independent experiments. *P <0.05, **P <0.01, ***P <0.001.