Research Paper Volume 12, Issue 14 pp 15058—15076

Figure 4. Cortical atrophy mediates the association between VRFs and cognitive function in the AD spectrum population. (A) Mediation effect of cortical atrophy linking the VRFs and MMSE in AD spectrum population. (B) Mediation effect of cortical atrophy linking the VRFs and ADAS-Cog in the AD spectrum population. All of the mediation effects and significance are computed by bootstrap sampling with 10,000 iterations. Effect sizes and 95% confidence intervals are displayed for each ROI. Abbreviations: LSPC, left superior parietal cortex; LPoCG, left postcentral gyrus; LIPC, left inferior parietal cortex; LPCUN, left precuneus; LFFA, left fusiform face area; RvmPFC, right ventromedial prefrontal cortex; RFFA, right fusiform face area; LTPJ, left temporoparietal junction; RMCC, right middle cingulate cortex; MMSE, Mini-Mental State Examination; ADAS-Cog, Alzheimer's Disease Assessment Scale-Cognitive Subscale; GMV, gray matter volume; VRF scores, vascular risk factor scores; ROI, region of interest; a, slope of VRF→ atrophy; b, slope of atrophy→ MMSE or ADAS-Cog; c^', slope of VRF→ MMSE or ADAS-Cog; a*b, the strength of the mediation pathway.