Research Paper Volume 12, Issue 17 pp 16852—16866
Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in C. elegans
Figure 4. Effects of spermidine on RNAi knockdown of pink1 and pdr-1 nematodes. (A) Effect of spermidine treatment on survival curves(n=85-101), lipofuscin deposition level(n=15), and locomotor capacity of wrn-1(gk99) worms(n=20). (B) Effect of spermidine treatment on survival curves(n=87-98), α-synuclein level(n=15), and locomotor capacity of NL5901 worms(n=20) (C) Effect of spermidine treatment on survival curves(n=92-97), lipofuscin deposition level(n=15), and locomotor capacity of UM0001 worms(n=20). Data are represented as mean± SD, *P < 0.05, **P < 0.01 vs control.