Research Paper Volume 12, Issue 14 pp 15121—15133

Megakaryocytes promote osteoclastogenesis in aging

Figure 7. Model showing OC stimulation by TPO and MKs in aging. The schema illustrates that aging increases MK number and alters MK-secreted factors, including RANKL, which together promote osteoclastogenesis. In addition, elevated TPO in the bone marrow cavity promotes direct and MK-mediated effects on OC formation in aged mice.