Research Paper Volume 12, Issue 17 pp 16963—16980

PGC-1α and ERRα in patients with endometrial cancer: a translational study for predicting myometrial invasion

Figure 3. Regulation of the migration and invasion ability of endometrial cancer cells by PGC-1α and ERRα. (A) Compared with blank groups (Blank), the 24-hour migrated distances of ECC-1 siPGC-1α group were significantly reduced. (B) Compared with blank groups (Blank), the 24-hour migrated distances of HEC-1A OV-ERRα group were significantly increased. (C) The endometrial cancer cells penetrated the Transwell membrane were significantly reduced in ECC-1 siPGC-1α group compared with Blank group. (D) the endometrial cancer cells penetrated the Transwell membrane were significantly increased in HEC-1A OV-ERRα group compared with Blank. Quantification of migration (E) and invasion (F) of ECC-1 cells. Quantification of migration (G) and invasion (H) of HEC-1A cells. *mean P<0.05, # mean P>0.05.