Research Paper Volume 12, Issue 17 pp 16963—16980

PGC-1α and ERRα in patients with endometrial cancer: a translational study for predicting myometrial invasion

Figure 5. Mechanism diagram to illustrate the potential role of ERRα/PGC-1α regulating EMT in endometrial cancer. High expression of PGC-1α/ERRα strengthening EMT phenotypes in endometrial cancer cells, the EMT process accompanied by the decreased expression of the epithelial cell marker E-cadherin, and the increased expression of the mesenchymal cell marker vimentin. Inhibition of PGC-1α/ERRα lead to suppresses the EMT process and upregulation of E-cadherin as well as downregulation of vimentin.