Research Paper Advance Articles

Sirt1 improves heart failure through modulating the NF-κB p65/microRNA-155/BNDF signaling cascade

Binding relationship between NF-κB p65 and miR-155. (A) miR-155 expression in heart tissues; (B) Enrichment of NF-κB p65 in the promoter region of miR-155 determined by ChIP assay; (C) miR-155 expression in cardiomyocytes; *p p p

Figure 3. Binding relationship between NF-κB p65 and miR-155. (A) miR-155 expression in heart tissues; (B) Enrichment of NF-κB p65 in the promoter region of miR-155 determined by ChIP assay; (C) miR-155 expression in cardiomyocytes; *p < 0.05 vs. control, oe-NC or sh-NC group; #p < 0.05 vs. sham group; ^p < 0.05 vs. model + sh-NC group. Data were expressed as a mean ± standard deviation. Three or more groups by one-way analysis of variance (ANOVA) and Tukey's post hoc test. N= 12.