Research Paper Volume 13, Issue 10 pp 14482—14498

Sirt1 improves heart failure through modulating the NF-κB p65/microRNA-155/BNDF signaling cascade

Effects of miR-155 and BDNF on heart failure in vivo. (A) Expression of miR-155 and BDNF mRNA expression; (B) BDNF protein expression; (C) Ventricular mass index; (D) CVF determined by Masson’s trichrome staining (100 ×); (E) Apoptosis determined by TUNEL staining (200 ×); *p

Figure 6. Effects of miR-155 and BDNF on heart failure in vivo. (A) Expression of miR-155 and BDNF mRNA expression; (B) BDNF protein expression; (C) Ventricular mass index; (D) CVF determined by Masson’s trichrome staining (100 ×); (E) Apoptosis determined by TUNEL staining (200 ×); *p < 0.05 vs. model + NC antagomir or model + miR-155 antagomir + sh-NC group. Data were expressed as mean ± standard deviation. A comparison of data from 2 groups were performed by unpaired t test. N= 12.