Research Paper Advance Articles

Sirt1 improves heart failure through modulating the NF-κB p65/microRNA-155/BNDF signaling cascade

Figure 7. Effects of Sirt1 overexpression on heart failure in vivo. (A) Sirt1, NF-κB p65, NF-κB p65 Ac and BDNF protein expression; (B) miR-155 expression; (C) Ventricular mass index; (D) CVF determined by Masson’s trichrome staining (100 ×); (E) Apoptosis determined by TUNEL assay (200 ×); *p < 0.05 vs. model + oe-NC group. Data were expressed as mean ± standard deviation. A comparison of data from 2 groups was performed by an unpaired t test. N= 12.