Glucose and cholesterol induce abnormal cell divisions via DAF-12 and MPK-1 in <i>C. elegans</i>

Zhi Qu; Shaoping Ji; Shanqing Zheng

doi:doi:10.18632/aging.103647

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Research Paper Volume 12, Issue 16 pp 16255—16269

Glucose and cholesterol induce abnormal cell divisions via DAF-12 and MPK-1 in C. elegans

Figure 3. Neuronal Q-cell divisions in glucose-, trehalose-, cholesterol-, and Δ⁷-dafachronic acid-treated L1-arrested worms are controlled by daf-12 and mpk-1. (A) Q-cell divisions resulting from glucose, trehalose, cholesterol, and Δ⁷-dafachronic acid treatments are not dependent on daf-16. Disruption of mpk-1 (B) and daf-12 (C) can suppress the Q-cell divisions in glucose-, trehalose- and steroid-treated wild-type, ins (oe), and daf-18 (-) (D) L1-arrested worms. More alleles of daf-12 and mpk-1 were tested to further confirm these results (Supplementary Figure 3). Data are the average of at least three independent experiments. Error bars: Standard Deviation (SD). ***: P<0.001.