Research Paper Volume 12, Issue 17 pp 17209—17223

CircRNA circ_0072995 promotes the progression of epithelial ovarian cancer by modulating miR-147a/CDK6 axis


Figure 3. circ_0072995 functioned as a sponge for miR-147a. (A) Potential targets of circ_0072995 as predicted by Starbase software and according to seed-matching sequence. (B) miR-147a was selected as the target of circ_0072995 due to its expression and was significantly increased among the four miRNAs after knockdown of circ_0072995. (C) The potential binding sites between miR-147a and circ_0072995. (D) The binding relationship between miR-147a and circ_0072995 was confirmed by dual-luciferase reporter assays. (E, F) miR-147a expression was markedly downregulated in EOC afflicted tissues and cell lines compared with normal groups, as determined by qRT-PCR.