Research Paper Volume 13, Issue 1 pp 228—240

Downregulation of miR-155-5p enhances the anti-tumor effect of cetuximab on triple-negative breast cancer cells via inducing cell apoptosis and pyroptosis

Downregulation of miR-155-5p enhances the anti-tumor effect of cetuximab in TNBC cells in vivo via inducing pyroptosis. (A) The expression levels of GSDME-N, cleaved caspase-1 and p-EGFR in tumor tissues were detected by Western blotting. (B, C) The relative expression levels of GSDME-N and cleaved caspase-1 in tumor tissues were normalized to β-actin. (D) The relative expression of p-EGFR in tumor tissues was normalized to EGFR. **P ##P

Figure 8. Downregulation of miR-155-5p enhances the anti-tumor effect of cetuximab in TNBC cells in vivo via inducing pyroptosis. (A) The expression levels of GSDME-N, cleaved caspase-1 and p-EGFR in tumor tissues were detected by Western blotting. (B, C) The relative expression levels of GSDME-N and cleaved caspase-1 in tumor tissues were normalized to β-actin. (D) The relative expression of p-EGFR in tumor tissues was normalized to EGFR. **P < 0.01 compared with the vehicle group. ##P < 0.01 compared with the cetuximab 10 nM group.