Research Paper Volume 12, Issue 18 pp 18209—18220

piR-19166 inhibits migration and metastasis through CTTN/MMPs pathway in prostate carcinoma


Figure 9. piR-19166 suppressed CTTN/ MMPs signaling pathways of PC3 in vivo. (A) piR-19166 overexpression remarkably inhibited the tumor volumes in vivo. (B) After 30 days post-injection, all mice were sacrificed, and subcutaneous tumors were collected. (C-D) The Immunohistochemistry (IHC) results showed that overexpression piR-19166 of xenograft tumor had distinctly lower the percentage of positive cells of p-CTTN, p-MT1-MMP, p-MMP2 and p-MMP9 than those of the control group. Error bars represent the mean ± SD of three independent experiments. *P <0.05, **P <0.01, ***P <0.001.