Research Paper Volume 12, Issue 16 pp 16390—16409

PRDX2 removal inhibits the cell cycle and autophagy in colorectal cancer cells

Figure 1. PRDX2 is upregulated in a variety of cancers, including CRC. (A) Expression of PRDX2 across TCGA tumors. Left panel: absolute expression values; right panel; expression in tumor versus normal samples. (B) Analysis of PRDX2 mRNA expression levels in normal and primary tumor tissues for breast invasive carcinoma (BRCA), cholangiocarcinoma (CHOC), liver hepatocellular carcinoma (LIHC), lung adenocarcinoma (LUAD), prostate adenocarcinoma (PRAD) and uterine corpus endometrial carcinoma (UCEC). (C) Analysis of PRDX2 mRNA expression levels between COAD and colon tissue according to histological subtypes, metastasis status, and individual cancer stages using the TCGA database through the UALCAN website. (D) Representative IHC photo images of PRDX2 protein expression in CRC tissues and normal colon tissues from The Human Protein Atlas website. ***P < 0.001 compared with the control group.