Figure 5. The effects of PRDX2 on the cell cycle and autophagy are mediated by the P38 pathway. (A) Western blots of MAPK signaling-related proteins. (B) Western blots of proteins related to the P38 pathway (P38 and p-P38), cell-cycle regulation (P21) and autophagy (LC3B) in sh-PRDX2 and control CRC cells with or without exposure to DHC (1 μM) for 24 h. (C) The ratio of LC3 II/I. The data are shown as the mean ± SD of three experiments. *P < 0.05, **P < 0.01, ***P < 0.001 compared with the control group.