Research Paper Volume 12, Issue 16 pp 16390—16409

PRDX2 removal inhibits the cell cycle and autophagy in colorectal cancer cells

Figure 5. The effects of PRDX2 on the cell cycle and autophagy are mediated by the P38 pathway. (A) Western blots of MAPK signaling-related proteins. (B) Western blots of proteins related to the P38 pathway (P38 and p-P38), cell-cycle regulation (P21) and autophagy (LC3B) in sh-PRDX2 and control CRC cells with or without exposure to DHC (1 μM) for 24 h. (C) The ratio of LC3 II/I. The data are shown as the mean ± SD of three experiments. *P < 0.05, **P < 0.01, ***P < 0.001 compared with the control group.