Research Paper Volume 12, Issue 16 pp 16390—16409

PRDX2 removal inhibits the cell cycle and autophagy in colorectal cancer cells

Figure 7. Sh-PRDX2 inhibits cell-cycle arrest and autophagy flux in vivo. (A) NC and sh-PRDX2 cells were transplanted in the mesenteric artery at the distal end of cecum of mice for 4 weeks. (B) The tumors were excised from the mesenteric artery. (C) Tumor weights were measured. IR: the tumor growth inhibition rate = (the average tumor weight of NC group - the average tumor weight of sh-PRDX2 group) / the average tumor weight of NC group. (D) Western blots of cell-cycle (left) and autophagy-related (right) proteins expressed in tumor cells. (E) The ratio of LC3 II/I. The data are shown as the mean ± SD . *P < 0.05, **P < 0.01, ***P < 0.001 compared with the control group.