Research Paper Volume 12, Issue 16 pp 16420—16436

Prognostic value and underlying mechanism of KIAA0101 in hepatocellular carcinoma: database mining and co-expression analysis

Figure 4. Survival analyses of KIAA0101 mRNA expression levels in HCC patients. (A) Survival analyses of KIAA0101 mRNA expression levels in HCC based on the Kaplan–Meier plotter database. Kaplan–Meier survival curves showed significant differences in OS between HCC patients with high and low KIAA0101 mRNA expression levels (HR=2.09, p=4.1e-05, log-rank test). (B) Survival analyses of KIAA0101 mRNA expression levels in HCC based on the Kaplan–Meier plotter database. Kaplan–Meier survival curves showed significant differences in OS between male HCC patients with high and low KIAA0101 mRNA expression levels (HR=2.6, p=0.00021, log-rank test). (C) Survival analyses of KIAA0101 mRNA expression levels in HCC based on the Kaplan–Meier plotter database. Kaplan–Meier survival curves showed significant differences in OS between female HCC patients with high and low KIAA0101 mRNA expression levels (HR=1.87, p=0.03, log-rank test). (D) Survival analyses of KIAA0101 mRNA expression levels in HCC based on the Kaplan–Meier plotter database. Kaplan–Meier survival curves showed significant differences in OS between early-stage (stage 1+2) HCC patients with high and low KIAA0101 mRNA expression levels (HR=2.34 p=0.00074, log-rank test). (E) Survival analyses of KIAA0101 mRNA expression levels in HCC based on the Kaplan–Meier plotter database. Kaplan–Meier survival curves showed significant differences in OS between advanced-stage (stage 3+4) HCC patients with high and low KIAA0101 mRNA expression levels (HR=1.93, p=0.031, log-rank test). (F) Survival analyses of KIAA0101 mRNA expression levels in HCC based on the Kaplan–Meier plotter database. Kaplan–Meier survival curves showed significant differences in OS between Asian HCC patients with high and low KIAA0101 mRNA expression levels (HR=4.68 p=4e-05, log-rank test). (G) Survival analyses of KIAA0101 mRNA expression levels in HCC based on the Kaplan–Meier plotter database. Kaplan–Meier survival curves showed significant differences in OS between Caucasian HCC patients with high and low KIAA0101 mRNA expression levels (HR=1.74 p=0.018, log-rank test). Abbreviation: HCC: hepatocellular carcinoma. OS: overall survival.