Research Paper Volume 13, Issue 6 pp 9119—9134

Silencing of circular RNA_0000326 inhibits cervical cancer cell proliferation, migration and invasion by boosting microRNA-338-3p-dependent down-regulation of CDK4

Silence of circ

Figure 3. Silence of circ_0000326 impairs cervical cancer cell migration and invasion. (A) Cervical cancer cell migration and invasion in HeLa and SiHa cell lines after silence of circ_0000326 detected by Transwell assay (× 200). (B) Number of migrating and invasive cells in HeLa and SiHa cell lines after silence of circ_0000326. (C) The influence of circ_0000326c silencing on the expression of MMP-2 and MMP-9 detected using Western blot analysis. * p < 0.05 vs. SiHa and Hela cells treated with NC. Data were expressed as mean ± standard deviation and analyzed by unpaired t test. Experiments were conducted 3 times independently.