Research Paper Volume 13, Issue 6 pp 9119—9134

Silencing of circular RNA_0000326 inhibits cervical cancer cell proliferation, migration and invasion by boosting microRNA-338-3p-dependent down-regulation of CDK4

Silencing of Circ

Figure 8. Silencing of Circ_0000326 inhibits tumor growth. (A) Effect of intratumoral LV-sh-circ_0000326 on tumor growth in BALB/c nude mice. (B) Representative images of the xenograft tumors in each group 3 weeks after subcutaneous implantation of SiHa cells stably infected with sh-circ_0000326 lentivirus or control lentivirus (LV-NC). (C) Effect of sh-circ_0000326 on tumor weight 3 weeks after subcutaneous injection of SIHA cells stably infected lv-sh-circ_0000326 or LV-NC. (D) Tumor sections were stained for CDK4 (in brown) and quantified by counting CDK4 positive staining area (pixels) (× 200). * p < 0.05. Data were expressed as mean ± standard deviation and verified by t-test, n = 10.