Research Paper Volume 12, Issue 17 pp 17353—17366

Taurine suppresses ROS-dependent autophagy via activating Akt/mTOR signaling pathway in calcium oxalate crystals-induced renal tubular epithelial cell injury

Figure 2. Tau attenuates EG-induced renal damage and crystal deposition in rat kidneys. (A) Effect of Tau on the serum expression of creatinine after EG-induced renal injury. (B) Effect of Tau on urea nitrogen following EG-induced renal injury. (C) Representative immunoblot and quantification analysis of IL-1β expression. (D) Renal tissue apoptosis was assessed by TUNEL staining; scale bar: 200 μm. (E) Kidney injury and crystal deposition were determined using Von Kossa-staining. Red and black arrows indicate glomerulus and crystal deposition, respectively; scale bar: 200 μm. Data are presented as the mean ± SD (n=3).*P < 0.05 versus the control group, #P < 0.05 versus the EG group.