Research Paper Volume 12, Issue 17 pp 17353—17366

Taurine suppresses ROS-dependent autophagy via activating Akt/mTOR signaling pathway in calcium oxalate crystals-induced renal tubular epithelial cell injury

Figure 4. Effects of Tau on EG-induced autophagic activity in rat kidneys. (A) The levels of LC3-II and p62 were examined by Western blot. (B) The expressions of LC3 and p62 in kidney tissues were detected by immunohistochemical staining; scale bar: 100 μm. (C) Detection of autophagic vacuoles in renal tissues by TEM. Red arrows: autophagic vacuoles; scale bar: 1 μm. Data are presented as the mean ± SD (n=3). *P < 0.05 versus the control group, #P < 0.05 versus the EG group.