Research Paper Volume 12, Issue 17 pp 17367—17379

G-protein coupled estrogen receptor activation protects the viability of hyperoxia-treated primary murine retinal microglia by reducing ER stress


Figure 7. GPER activation maintains ER calcium concentration in the hyperoxia-treated primary retinal microglia. (A) The bar graphs show the ER calcium concentrations at 12, 24, 48 and 72 h in the (a) control (C), (b) hyperoxia (H), (c) hyperoxia+DMSO (DMSO), (d) hyperoxia+G-1 (G-1), and (e) hyperoxia+G-1+G-15 (G-1+G-15) groups of primary retinal microglia. (B) The curves show the change in ER calcium concentration in each of the five groups of primary retinal microglia between 12-72h. P<0.05 denotes statistical significance. The experiments were repeated thrice and means±S.D are shown.