Research Paper Volume 13, Issue 10 pp 14499—14521

Identification of a 15-pseudogene based prognostic signature for predicting survival and antitumor immune response in breast cancer

Immune cell infiltration and expressions of antigen presenting genes, immune cytolysis genes and immunomodulator genes in tumor tissues by P1/P2 subgroups. (A) Comparisons of cell composition fraction of CD8+ T cells, CD4+ T cells, helper T cells, regulatory T cells, activated natural killer (NK) cells, monocytes, M1 macrophages, M2 macrophages, activated dendritic cells (activated DCs) and neutrophils between P1 and P2 subgroups. (B) Expressions of HLA-A, HLA-B, HLA-C, TAP1 and B2M between P1 and P2 subgroups. (C) Expressions of GZMA and PRF1 between P1 and P2 subgroups. (D) Expressions of PD-1, PD-L1, PD-L2, LAG3, TIM3, CTLA-4, CCR4, TIGIT, CD27 and ICOS between P1 and P2 subgroups.

Figure 5. Immune cell infiltration and expressions of antigen presenting genes, immune cytolysis genes and immunomodulator genes in tumor tissues by P1/P2 subgroups. (A) Comparisons of cell composition fraction of CD8+ T cells, CD4+ T cells, helper T cells, regulatory T cells, activated natural killer (NK) cells, monocytes, M1 macrophages, M2 macrophages, activated dendritic cells (activated DCs) and neutrophils between P1 and P2 subgroups. (B) Expressions of HLA-A, HLA-B, HLA-C, TAP1 and B2M between P1 and P2 subgroups. (C) Expressions of GZMA and PRF1 between P1 and P2 subgroups. (D) Expressions of PD-1, PD-L1, PD-L2, LAG3, TIM3, CTLA-4, CCR4, TIGIT, CD27 and ICOS between P1 and P2 subgroups.