Research Paper Volume 12, Issue 16 pp 16476—16490

Relationship closeness buffers the effects of perceived stress on transcriptomic indicators of cellular stress and biological aging marker p16INK4a

Figure 2. Cell stress transcription factor activity based on levels of perceived stress in parents with low (scores of 0–3 on the IOS scale) relative to high (scores of 4–5 on the IOS scale) relationship closeness, expressed as a Mean Log2 Ratio of transcription factor binding motif prevalence in the promoter regions of up-regulated versus down-regulated genes, averaged across nine parametric variations.