Research Paper Volume 12, Issue 17 pp 17436—17458

Jinmaitong ameliorates diabetic peripheral neuropathy in streptozotocin-induced diabetic rats by modulating gut microbiota and neuregulin 1

Figure 4. JMT inhibited APP expression and promoted serum NRG1 level in DPN rats. (A) Representative images of longitudinal sections of sciatic nerves with immunolabeling for APP (green), βIII-tubulin (red), and DAPI (blue, marking nuclei) at a magnification of 400×; scale bars, 20 μm. (B) Percentage of APP+ axonal area with βIII-tubulin colocalization. (C) Panels of serum NRG1 level in different groups. Means ± SD; n=3-8/group. ****p < 0.0001, **p < 0.01 vs. normal control group; ††p < 0.01, †p < 0.05 vs. distilled water-treated DPN group. One-way ANOVA followed by Tukey’s multiple comparison test.