Research Paper Volume 12, Issue 17 pp 17436—17458

Jinmaitong ameliorates diabetic peripheral neuropathy in streptozotocin-induced diabetic rats by modulating gut microbiota and neuregulin 1

Figure 6. JMT modulated microbiota composition in DPN rats. Alpha diversity was evaluated by examining (A) the observed species diversity index, (B) Shannon index, and (C) Simpson index of fecal samples from different groups. Each box plot represents the median, interquartile range, minimum and maximum values. Principal coordinate analysis (PCoA) on (D) unweighted and (E) weighted UniFrac distances among different groups. Boxplots show the distribution of samples along the given axis, representing the median and interquartile range. Ellipses represent a 95% confidence interval around the cluster centroid. Clustering significance by body site was determined by Adonis (p < 0.001).