Research Paper Volume 12, Issue 17 pp 17459—17479

Figure 7. Combined targeted therapy simulated in vivo. (A) A schematic diagram of subcutaneous xenograft schedule. (B) LINC00160 knockdown 786-O-R cells were subcutaneously injected into the flanks of nude mice. Xenografts were harvested after 8 weeks. (C) Tumor weight was measured after resection. Tumor volume was calculated every week. (D, E) Immunohistochemistry staining for p-STAT3 and c-PARP1 were examined. Black scale bar represents 50 μm (E). Fold changes were presented (D). (F) A schematic diagram indicated LINC00160 regulatory network during resistant process. Data was represented as mean ± SEM. *P<0.05, **P<0.01 and ***P<0.001. LINC00160, long non-coding RNA 160; p-STAT3, phosphorylated signal transducer and activator of transcription 3; c-PARP1, cleaved poly (ADP-ribose) polymerase 1.