Research Paper Volume 12, Issue 18 pp 18476—18500

YTHDF2 correlates with tumor immune infiltrates in lower-grade glioma

Figure 4. Correlation of YTHDF2 expression with IDH1 level in LGG. (A) High IDH1 expression was correlated with poor OS in the LGG GEPIA dataset. (B) LGG patients with IDH1 mutations had superior OS in the dataset from cBioPortal for Cancer Genomics. (C) IDH1 mutation led to a superior OS in gliomas. (D) IDH1 expression was not correlated with OS in the AML in GEPIA dataset. (E, F) YTHDF2 expression had a positive relationship with IDH1 in LGG and AML. (G) The immune infiltration levels were higher in IDH1-wild-type than in IDH1-mutant LGG. AML, acute myeloid leukemia; LGG, lower-grade glioma; OS, overall survival.