Research Paper Volume 12, Issue 17 pp 17625—17633

Graphene oxide inhibits cell migration and invasion by destroying actin cytoskeleton in cervical cancer cells

Figure 5. Smad and JNK signaling pathways are associated with the inhibitory effect of graphene oxide (GO) on tumor metastasis in Hela cells. The expression of MMP3 and ICAM in Hela cells co-treated with GO and Smad inhibitor, NF-kB inhibitor, p53 inhibitor, Erk inhibitor or JNK inhibitor by western blotting. **P < 0.01 vs control group, #P < 0.05, and ##P < 0.01 vs GO group.