Research Paper Volume 12, Issue 18 pp 18522—18544

GPA peptide inhibits NLRP3 inflammasome activation to ameliorate colitis through AMPK pathway

Figure 7. Putative mechanism for the anti-inflammatory effect of GPA in macrophages. GPA increased AMPK phosphorylation to suppress ROS and mtDNA production, resulting in the blocking of NLRP3 mitochondrial translocation, which inhibited NLRP3 inflammasome activation and pyroptosis.