Figure 2. Response of β1AR- and M5R-Aabs to therapy. Serum levels of β1AR-Aabs (white) were measured by IgG-binding to a cyclic peptide representing the presumed pathogenic conformational auto-epitope within the second extracellular loop of the receptor. M5R-Aabs (black) were measured by IgG-binding to the native receptors (CellTrend GmbH). Values obtained at 5 and 17 weeks after therapy (early), 30 and 44 weeks after therapy (intermediate) and 58 to 112 weeks after therapy (late) are normalized to pre-therapeutic values (dotted line). Data of n=66 patients undergoing complete follow up are given as median ± interquartile range. *** indicate differences to pre-therapy values at p < 0.001 significance.