Research Paper Volume 12, Issue 17 pp 17681—17693

Long non-coding RNA Loc490 inhibits gastric cancer cell proliferation and metastasis by upregulating RNA-binding protein Quaking

Figure 1. Low expression of Loc490 in GC and lymph node metastasis tissue. (A) RNA quality testing (C: GC tissue; L: lymph node metastasis tissue; N: normal tissue adjacent to GC); (B) Screening for differentially expressed lncRNAs using Agilent Human LncRNA chip technology in normal tissues adjacent to GC, primary GC tissues and lymph node metastasis tissues; (C) Loc490 expression was significantly lower in lymph node metastases than in normal tissues adjacent to GC and in primary GC tissue (the other selected genes are shown in the article); (D) qRT-PCR results demonstrating Loc490 expression in 28 normal tissues adjacent to GC, primary GC tissues and lymph node metastasis tissues; (E) Expression of QKI mRNA in 28 normal tissues adjacent to GC, primary GC tissues and lymph node metastases; (F) Correlation analysis demonstrating that Loc490 expression was significantly positively correlated with QKI mRNA expression. Data represent the mean and SD from three experiments. **p < 0.01, ***p < 0.001.