Figure 5. Inhibit QKI expression by interfering Loc490 expression in GC cells and affect the biological behavior. (A) Loc490 mutations at two binding sites; (B, C) Expression of Loc490 and QKI; (D, E). Invasion and proliferation assay results in SGC-7901 cells; (F) Tumor volume in each group of nude mice; (G) Representative tumors from each group are shown after three weeks (time calculated one week after the subcutaneous inoculation of the nude mice). (A: Vector + siControl, B: Loc490 + siControl, C: Loc490 + siQKI). Scale bars: 100 μm. Data represent the mean and SD from three experiments. **p < 0.01, ***p < 0.001.