Research Paper Volume 13, Issue 1 pp 262—278

Combined transplantation of neural stem cells and bone marrow mesenchymal stem cells promotes neuronal cell survival to alleviate brain damage after cardiac arrest via microRNA-133b incorporated in extracellular vesicles

Systematic diagrams sketching the protection of combined transplantation of BMSCs and NSCs in CA-induced neurological impairment. BMSCs promote NSC differentiation into neuronal cells and NSCs stimulate BMSCs to release EVs harboring miR-133b into the neuronal cells thereby facilitating neuronal cell survival.

Figure 7. Systematic diagrams sketching the protection of combined transplantation of BMSCs and NSCs in CA-induced neurological impairment. BMSCs promote NSC differentiation into neuronal cells and NSCs stimulate BMSCs to release EVs harboring miR-133b into the neuronal cells thereby facilitating neuronal cell survival.