Research Paper Volume 12, Issue 18 pp 18676—18692

Identification of genomic alterations and associated transcriptomic profiling reveal the prognostic significance of MMP14 and PKM2 in patients with pancreatic cancer

Figure 3. Identification of genomic alterations associated transcriptomic profiling. (A) Venn diagram depicted the number of commonly regulated genes by KRAS mutation, TP53 mutation and CDKN2A deletion in TCGA PAAD datasets. (B) Unsupervised clustering heatmap demonstrated the commonly regulated genes by KRAS mutation, TP53 mutation and CDKN2A deletion in TCGA PAAD datasets. Up-regulated (red), down-regulated (green) and unchanged (black) genes were delineated. (C) Functional pathway enrichment analysis of KRAS mutation, TP53 mutation and CDKN2A deletion commonly regulated genes using DAVID. The most significantly enriched pathways were shown. (D) Box plots showed the ERBB2 expression levels (log2 normalization count) in TCGA pancreatic cancer patients with or without genomic alterations. P values were performed using Student’s t test. (E) Box plots showed the SMAD4 expression levels (log2 normalization count) in TCGA pancreatic cancer patients with or without genomic alterations.