Research Paper Volume 12, Issue 24 pp 25101—25119

Could microtubule inhibitors be the best choice of therapy in gastric cancer with high immune activity: mutant DYNC1H1 as a biomarker

Figure 4. Association of mutant genes with high immune activity in TCGA-STAD and NCI-60 cell lines datasets. Levels of TMB, MSI score, and mRNA expression in TCGA-STAD (AC) and NCI-60 cell lines (DF), stratified by genes (DYNC1H1, CENPF, and KIF26B) mutation status. MUT: mutated, WT: wild type. KIF26B was not detected in NCI-60 cell lines dataset. All p-values were obtained by Student’s t-test, in addition to χ2 test for (E). P-value < 0.05 was considered significant.