Research Paper Volume 12, Issue 24 pp 25101—25119

Could microtubule inhibitors be the best choice of therapy in gastric cancer with high immune activity: mutant DYNC1H1 as a biomarker

Figure 5. Association of mutant DYNC1H1 with enhanced microtubule inhibitors (MTIs) activities in NCI-60 cell lines dataset. (A) Volcano plot for the different activities of MTIs between DYNC1H1 mutated and wild type NCI-60 cell lines dataset. The x-axis represented the different levels of mean -logGI50, and the y-axis showed p-values obtained by Student’s t-test. (BE) Histograms depicting different MTIs activities of nocodazole (B), docetaxel (C), colchicine (D), vincristine (E), stratified by DYNC1H1 mutation status in NCI-60 cell lines dataset (p-value < 0.05 by Student’s t-test). MUT: mutated, WT: wild type. P-value <0.05 was considered significant. DYNC1H1 was mutated in six NCI-60 cell lines: HCC_2998, HCT_116, HCT_15, KM12, MOLT_4, and UACC_62.