Research Paper Volume 12, Issue 24 pp 25120—25137

Apelin protects against ischemia-reperfusion injury in diabetic myocardium via inhibiting apoptosis and oxidative stress through PI3K and p38-MAPK signaling pathways

Figure 1. Examination for the cardiomyocyte’s function in ischemia reperfusion (IR) injury. (A, B) The IR injury was detected by the TTC staining. P<0.001 compared to ND-IRI group. (C) The cardiac pathology was evaluated by HE staining. Magnification, ×200. TTC: triphenyltetrazoliu chloride; HE: Hematoxylin-eosin; ND-Sham: Non-diabetes sham group; ND-IRI: Non-diabetes ischemia reperfusion injury; D-IRI: Diabetes ischemia reperfusion injury; D-Sham: Diabetes sham group.