Apelin protects against ischemia-reperfusion injury in diabetic myocardium via inhibiting apoptosis and oxidative stress through PI3K and p38-MAPK signaling pathways

Songtao An; Xi Wang; Huairui, Shi; Xueqiang Zhang; Hua Meng; Wenbo Li; Dongchang Chen; Junbo Ge

doi:doi:10.18632/aging.104106

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Research Paper Volume 12, Issue 24 pp 25120—25137

Apelin protects against ischemia-reperfusion injury in diabetic myocardium via inhibiting apoptosis and oxidative stress through PI3K and p38-MAPK signaling pathways

Figure 3. Evaluation for the levels of Apelin in diabetic- or no diabetic IRI rats. The levels of Apelin in both cardiomyocyte (A) and serum (B) were evaluated by ELISA kit. ^* P<0.05, ^**P<0.01, ^***P<0.001 represent the values compared to the ND-Sham group. ^### P<0.001 represents the values compared to the D-Sham group. ^$$$P<0.001 represents the values compared to the First week. ND-Sham: Non-diabetes sham group; ND-IRI: Non-diabetes ischemia reperfusion injury; D-IRI: Diabetes ischemia reperfusion injury; D-Sham: Diabetes sham group.